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Decompilation of High-Level Constructions in C++ Binaries
Jakub, Dušan ; Křivka, Zbyněk (referee) ; Matula, Peter (advisor)
The thesis addresses the decompilation of high-level object-oriented C++ language from a machine code. The term reverse engineering is defined and existing decompilers are described with emphasis on their ability to reconstruct C++. AVG decompiler project is introduced, to which this thesis contributes. C++ language is analysed, both on a logical level and in the machine code and existing methods of decompilation are described. On this basis a novel method is introduced, capable of decompiling classes, their hierarchy, constructors, destructors and definitions and usages of virtual methods. The method is implemented, tested and evaluated. In the conclusion, several suggestions for future development of this project are presented.
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Design and Analysis of Reservation Teaching System
Jiříček, Milan ; Lukáš, Roman (referee) ; Fiala, Jiří (advisor)
In this bachelor's thesis there is a detailed description of an information systems analysis and design. An attention paid to implementation of such system is also specified in further details. Techniques of procedure designing of these systems using UML are described on a specific case of reservation teaching system. This information system works with specific events, either a regular class or a one-time event. Particular users of this system are able to carry out actions, which are linked with event management as well as with subjects or classrooms.
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Teaching Genetics with a Focus on Human Phenotypic Traits
Heidelberg, Jiří ; Ehler, Edvard (advisor) ; Vančata, Václav (referee)
This thesis focuses on the inheritance of human phenotypic traits within the framework of genetics teaching at Czech grammar schools. Outlines information important to understanding the inheritance of human phenotypic traits. All fundamentals of genetics will be covered, including examples from human genetics and examples from nature. At the same time, he is engaged in a research investigation at selected Czech grammar schools, where we will try to find out the degree of knowledge of genetics that the pupils have. Attention is also paid to the influence of the classroom climate on pupils' knowledge, which is an important aspect in acquiring knowledge. The influence of the teacher's personality on the climate in the classroom is related to this. the results of the research survey from the data collected using the online questionnaire show the level of knowledge of the respondents and any gaps that need to be worked on. KEYWORDS Inheritace, phenotype, human genetics, education, pedagogy
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Selected Members of the Habsburg Dynasty and their Mental Disorders
Grunclová, Kateřina ; Ehler, Edvard (advisor) ; Vančata, Václav (referee)
This Bachelor thesis presents research into occurring mental illnesses in celected members of the Habsburg dynasty, with an effort to best consretise them from the original historical background and to compare them with current knowledge. At the same time, it will describe the marriage policy that cintributed to the emergence of mental illness in individual members. The aim of the work is to get acquainted with the Habsburg dynasty, characterize the mental disorders occurring in this magnificent dynasty and evaluate the manifestations of individual diseases.
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Heredity of polledness in cattle
HEGROVÁ, Kateřina
Most cattle breeds were originally naturally horned. The horns were used as a tool of defense and a manifestation of dominance in the herd. With increasing pressure to increase the efficiency of breeding and increase the safety of both animals and care-givers, horned cattle are being dehorned. However, this does not correspond with welfare requirements. In 2009, the complete genome of cattle was sequenced, which started a series of researches in the field of heredity. Genetic manifestations of horns or polledness are controlled by the autosomal locus polled, located on chromosome pair BTA1, characterized by two alleles, for the dominant P allele representing polledness, and for the recessive allele p for horns. In cattle we encounter 4 mutations of these alleles Celtic, Frisian, Mongolian and Guarany. Manifestations of polledness are also influenced by alleles for the presence of scurrs Sc and sc, or alleles for the manifestation of the so-called African horns Af and An. Thanks to the testing of individuals using microsatellite markers or the SNP method, it is possible to mark genetically polled individuals and thus help breeders to expand hornless breeds.
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Detection of mutation causing plycystic kidney disease
SLÁDKOVÁ, Nikola
In my bachelor's thesis, I dealt with the detection of the mutation in the PKD2 gene, which causes polycystic kidney disease. The disease is interesting because it is not only caused by a single specific mutation that affects a particular gene, but the disease is highly variable and can be caused by several mutations located on different chromosomes and even at different sites in a given exon. The subject of my research was a family of four. Based on the results of using clinical diagnostics, one member of the family was confirmed to have polycystic kidney disease. The aim of this thesis was to detect the possible PKD2 mutation in the family members, and thus to confirm the presence of polycystic kidney disease. The next aim was the optimization of the designed primers for the PCR reaction. In the theoretical section of this thesis, I focused on the issue of polycystic kidney disease, classification of polycystic kidney disease based on the inheritance type, and the protein products of the PKD2 and PKD1 genes. I also mentioned the anatomy of the kidneys, their function, and also the structure of a nephron. I also dealt with the health problems that accompany the disease, as well as its diagnostics and subsequent treatment. In the practical section of this thesis, I described the process of the laboratory diagnostics used to search for a mutation in the PKD2 gene, specifically in its first five exons. The diagnostics consisted of the DNA isolation, PCR reaction, gel electrophoresis, and subsequent Sanger sequencing. However, due to limited laboratory capacity, I did not personally perform the Sanger sequencing. The samples prepared for sequencing were sent to the SEQme company. In the end, I examined the electrophoreograms and the results from the obtained sequences. I had a total of 20 sequenced samples for the evaluation, always 4 samples for each exon. I was not able to prove the possible mutation in any of them. The remaining exons would also need to be examined for a complete diagnostics of the disease.
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Hereditary monogenic health disorders in canine breeds in relation to breeding
ORSÁKOVÁ, Kamila
This thesis deals with problematic of prevalence of single-gene disorders for various dog breeds. The goal was to discover the groups of dog breed with the highest prevalence of single-gene disorders and discover which of these disorders tends to affects most of the dog breeds. We have evaluated 23 closely related groups of dog breeds (Parkerová et al. 2017) with the appearance of some single-gene disorder as we predicted based on our analysis based on OMIA database dated to year 2018-2020. The analysis showed us that the Neuronal Ceroid Lipofuscinosis (NCL) and Progressive Rod-Cone Degeneration (PRCD) affecting most of the dog breeds. We also discovered that the genetically closely related dog breed group 20T, which contains 16 dog breeds, suffers from over 49 types of single-gene disorders. We also discovered that the Border Collie is the dog breed with the highest single-gene disorder prevalence in previously mentioned group 20T. This dog breed is affected by 9 disorders at least. In our analysis the dog breed Labrador Retriever and German Shepherd are suffering from most types of single-gene disorder (more than 15). These dog breeds are one of the most common dog breeds in Czech Republic. This finding supports the hypothesis that the popular dog breeds tends to have better mapped genome and are subjects of testing more often. This thesis provides the characteristic of selected dog breeds. The genetic specifications also contains the recommended breeding method parameters for the minimization of disorders in population.
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Absolute Pitch: Theoretical Concept and Practical Issues
Bártová, Jitka ; Váňová, Hana (advisor) ; Pecháček, Stanislav (referee)
The thesis aims at complex assessment of absolute pitch both theoretically and practically. It describes the functioning of ear and main issues related to processing of sound and tone height. In addition, it clarifies related terms stemming from musical psychology. Especially, it endeavours to identify causes of absolute pitch and factors which form it. The thesis surveys several phenomena connected with absolute pitch, for example with synesthesia, and with other aspects such as occurrence of absolute pitch among population. It uses not only the Czech but especially English written literature which has not yet been used in such a scope in the Czech musical research.
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Comparison of effectiveness of teaching using computers vs. 3D models
Andělová, Denisa ; Janštová, Vanda (advisor) ; Jáč, Martin (referee)
Currently, pupils' interest in science continues to decline, although this area of education is very important in every day life (medicine, environment, etc.) and there is high demand for science professions on the labor market. Molecular biology curriculum concerning DNA and the transfer of genetic information is abstract and difficult topic for pupils to imagine, and for teachers to explain. There are many ways to teach this topic. Very popular are iquiry and laboratory practise. But not all schools have their own laboratories, and can teach molecular practical effectivelly. Inquiry based teaching is time consuming to prepare, and not every topic is appropriate to be taught this way. Another possibilities how to visualize "invisible" molecules and processes are computer software and animations or 3D physical model. In my thesis, I examined the effect of using computers and animations to teach abou DNA compared to using a 3D physical model on students' knowledge. I laso tested the possible influence of gender and pupils' preferences on their achieved score on knowledge tests. The research was performed in five classes at three high schools in Prague. Students in year 12 were on different types of high school and some of them took special biology class, their age was between 15 and 18 years. The...
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